Size  100ul
Cat code  220037
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Clone Number  1H4-A4-A2
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG1
Molecular Weight  26kDa
Sensitivity  The antibody detects endogenous level of GSTM1 protein.
Immunogen  Purified recombinant fragment of human GSTM1 expressed in E. Coli.
UniProt Number  P09488
GeneBank ID  NM_146421.2
Subcellular location  Cytoplasm.
Formulation  Ascitic fluid containing 0.03% sodium azide.
Altername  Glutathione S alkyltransferase; Glutathione S aralkyltransferase; Glutathione S aryltransferase; Glutathione S transferase M1; Glutathione S transferase mu 1; Glutathione S transferase mu; Glutathione S-transferase Mu 1; GST class mu 1; GST class Mu; GST class-mu 1; GST HB subunit 4; GST mu; GST1; GSTM1 1; Gstm1; GSTM1-1; GSTM1_HUMAN; GSTM1a 1a; GSTM1a-1a; GSTM1b 1b; GSTM1b-1b; GTH4; GTM1; H B; HB subunit 4; MGC26563; MU 1; MU; S (hydroxyalkyl)glutathione lyase;
Gene_symbol  MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
Summary  Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual´s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
UniPort summary  Function  Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Application Images :  
Western blot detection of GSTM1 antibody in MCF7,Jurkat and Hela cell lysates using GSTM1 antibody (dilution 1:1000). Predicted band size:26 KDa. Observed band size: 26KDa.