Size  100ug
Cat code  200766
Species Cross-reactivity  H,Mk
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  null
Isotype  IgG1
Molecular Weight  72kDa
Sensitivity  This antibody detects endogenous levels of BIRC3 and does not cross-react with related proteins.
Immunogen  Purified recombinant c-IAP2 protein fragments expressed in E.coli
UniProt Number  Q13489
GeneBank ID  NM_001165
Subcellular location  Cytoplasm.Nucleus
Formulation  ascites
Altername  CIAP 2;Inhibitor of apoptosis protein 1;AIP 1;AIP1;API 2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;C IAP2;CIAP 2;CIAP2;HAIP 1;HAIP1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;
Gene_symbol  AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; MALT2; RNF49; c-IAP2
Summary  This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases.The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione,a potent inducer of free radicals.It contains 3 baculovirus IAP repeats and a ring finger domain.Transcript variants encoding the same isoform have been identified.[provided by RefSeq,Aug 2011]
UniPort summary  Function  Multi-functional protein which regulates not only caspases and apoptosis,but also modulates inflammatory signaling and immunity,mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions:acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1,RIPK2,RIPK3,RIPK4,CASP3,CASP7,CASP8,TRAF1,and BCL10.Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors(TLRs),Nodlike receptors (NLRs) and RIG-I like receptors (RLRs),collectively referred to as pattern recognition receptors (PRRs).Protects cells from spontaneous formation of the ripoptosome,a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Application Images :  
Western blot detection of BIRC3 in Ramos,COS7,Raji&Daudi cell lysates using BIRC3 antibody(1:1000 diluted).Predicted band size: 68KDa,Observed band size:72KDa