Size  100ug
Cat code  200585
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG2b
Molecular Weight  32kDa
Sensitivity  This antibody detects endogenous levels of SDCBP and does not cross-react with related proteins.
Immunogen  Purified recombinant human SDCBP protein fragments expressed in E.coli.
UniProt Number  O00560
GeneBank ID  NM_001007067.1
Subcellular location  Nucleus. Cytoplasm. Mitochondrion. Note: Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  Melanoma differentiation-associated protein 9
Short name=MDA-9
Pro-TGF-alpha cytoplasmic domain-interacting protein 18
Short name=TACIP18
Scaffold protein Pbp1
Syndecan-binding protein 1
Gene_symbol  ST1; SYCL; MDA-9; TACIP18 
Summary  The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniPort summary  Function  Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Application Images :  
Western blot detection of SDCBP in HelaNE&Hela cell lysates using SDCBP antibody (1:1000 diluted).
Predicted band size:32KDa
Observed band size:32KDa.