Size  100ug
Cat code  200898
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  70kDa
Sensitivity  This antibody detects endogenous levels of IGF2BP3 and does not cross-react with related proteins.
Immunogen  Purified recombinant human IGF2BP3 protein fragments expressed in E.coli.
UniProt Number  O00425
GeneBank ID  NM_006547
Subcellular location  Nucleus.Cytoplasm.
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Altername  Cancer/testis antigen 98;CT98;DKFZp686F1078;hKOC;IF2B3_HUMAN;IGF II mRNA binding protein 3;IGF-II mRNA-binding protein 3;IGF2 mRNA binding protein 3;IGF2 mRNA-binding protein 3;IGF2BP3;IMP 3;IMP-3;Insulin like growth factor 2 mRNA binding protein 3;Insulin-like growth factor 2 mRNA-binding protein 3;KH domain containing protein overexpressed in cancer;KH domain-containing protein overexpressed in cancer;KOC 1;KOC1;VICKZ 3;VICKZ family member 3;VICKZ3.
Gene_symbol  CT98;IMP3;KOC1;IMP-3;VICKZ3.
Summary  The protein encoded by this gene is primarily found in the nucleolus,where it can bind to the 5´ UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.The encoded protein contains several KH domains,which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.A pseudogene exists on chromosome 7,and there are putative pseudogenes on other chromosomes.[provided by RefSeq,Jul 2008]
UniPort summary  Function  RNA-binding protein that act as a regulator of mRNA translation and stability.Binds to the 5´-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.Binds to sequences in the 3´-UTR of CD44 mRNA.
Application Images :  
Western blot detection of IGF2BP3 antibody in MCF7,SKVO3,NTERA2,Jurkat,Hela and K562 cell lysates using IGF2BP3 antibody (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.