Size  100ul
Cat code  220027
Species Cross-reactivity  H,Mk
Key Application  WB
Host  Mouse
Clone Number  2C12-D10-F1
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  67.8kDa
Sensitivity  The antibody detects endogenous level of total MSN protein.
Immunogen  Purified recombinant fragment of human MSN expressed in E. Coli.
UniProt Number  P26038
GeneBank ID  NM_002444.2
Subcellular location  Cell membrane. Cytoplasm > cytoskeleton. Apical cell membrane. Cell projection > microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
Formulation  Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Altername  Membrane organizing extension spike protein ; Membrane-organizing extension spike protein ; MOES_HUMAN ; Moesin ; Moesin/anaplastic lymphoma kinase fusion protein ; Msn ; MSN/ALK fusion ;
Gene_symbol  
Summary  Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
UniPort summary  Function  Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.
Application Images :  
Western blot detection of MSN antibody in COS7, Jurkat, HaCat and Hela cell lysates using MSN antibody(dilution 1:500).Predicted band size:67.8KDa.Observed band size:67.8KDa.