Size  100ug
Cat code  200591
Species Cross-reactivity  M
Key Application  WB,ICC
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  57kDa
Sensitivity  This antibody detects endogenous levels of CHRDL1 and does not cross-react with related proteins.
Immunogen  Purified recombinant human CHRDL1 protein fragments expressed in E.coli.
UniProt Number  Q9BU40
GeneBank ID  NM_145234.3
Subcellular location  Secreted
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  Neuralin-1
Neurogenesin-1
Ventroptin
Gene_symbol  CHL; VOPT; NRLN1; dA141H5.1
Summary  This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. 
UniPort summary  Function  Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation By similarity. May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.
Application Images :  
Western blot detection of CHRDL1 in Rat kidney tissue lysates using CHRDL1 antibody (1:1000 diluted).
Predicted band size: 57kDa
Observed band size: 57kDa
Immunocytochemistry stain of Hela using CHRDL1 antibody (1:300).