Size  100ul
Cat code  220034
Species Cross-reactivity  H, R, M
Key Application  WB
Host  Mouse
Clone Number  5H7-D5-E2
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG1
Molecular Weight  30kDa
Sensitivity  The antibody detects endogenous level of PHB protein.
Immunogen  Purified recombinant fragment of human PHB expressed in E. Coli.
UniProt Number  P35232
GeneBank ID  NM_002634.2
Subcellular location  Mitochondrion inner membrane
Formulation  Ascitic fluid containing 0.03% sodium azide.
Altername  PHB; PHB_HUMAN; PHB1; Prohibitin;
Gene_symbol  PHB1
Summary  This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3´ UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniPort summary  Function  Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Application Images :  
Western blot detection of PHB antibody in C6, COS7, 3T3 and Hela cell lysates using PHB antibody (dilution 1:1000).Predicted band size:30 KDa.Observed band size:30KDa.