Size  100ug
Cat code  200679
Species Cross-reactivity  H,M,Mk,R
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgM
Molecular Weight  78kDa
Sensitivity  This antibody detects endogenous levels of CRTC1 and does not cross-react with related proteins.
Immunogen  Purified recombinant human CRTC1 protein fragments expressed in E.coli.
UniProt Number  Q6UUV9
GeneBank ID  NM_015321
Subcellular location  Cytoplasm. Nucleus.
Formulation  ascites
Altername  KIAA0616;CREB regulated transcription coactivator 1;CREB-regulated transcription coactivator 1;CRTC1;CRTC1_HUMAN;FLJ14027;KIAA0616;MECT 1;Mucoepidermoid carcinoma translocated 1;Mucoepidermoid carcinoma translocated protein 1;TORC-1;TORC1;Transducer of CREB protein 1;Transducer of regulated cAMP response element binding protein 1;Transducer of regulated cAMP response element-binding protein (CREB) 1;Transducer of regulated cAMP response element-binding protein 1;WAMTP1.
Gene_symbol  MECT1;TORC1;TORC-1;WAMTP1.
Summary  
UniPort summary  Function  Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.
Application Images :  
Western blot detection of CRTC1 antibody in Hela,mouse brain,SW480,COS7,C6 and 3T3 cell lysates using CRTC1 antibody (1:2000 diluted).Predicted band size:78KDa.Observed band size:78KDa.