Size  100ug
Cat code  200921
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  130kDa
Sensitivity  This antibody detects endogenous levels of PECAM1 and does not cross-react with related proteins.
Immunogen  Purified recombinant human PECAM1 protein fragments expressed in E.coli.
UniProt Number  P16284
GeneBank ID  NM_000442.3
Subcellular location  Isoform Long: Membrane;Single-pass type I membrane protein.Cell junction.Isoform Delta15: Cell junction.
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Altername  Adhesion molecule;CD31;CD31 antigen;CD31 EndoCAM;Endocam;FLJ34100;FLJ58394;GPIIA;GPIIA´;PECA1;PECA1_HUMAN;Pecam 1;PECAM 1 CD31 EndoCAM;PECAM-1;Pecam1;Platelet endothelial cell adhesion molecule;Platelet/endothelial cell adhesion molecule 1;Platelet/endothelial cell adhesion molecule.
Adhesion molecule;CD31;CD31 antigen;CD31 EndoCAM;Endocam;FLJ34100;FLJ58394;GPIIA;GPIIA´;PECA1;PECA1_HUMAN;Pecam 1;PECAM 1 CD31 EndoCAM;PECAM-1;Pecam1;Platelet endothelial cell adhesion molecule;Platelet/endothelial cell adhesion molecule 1;Platelet/endothelial cell adhesion molecule.
Gene_symbol  Cd31;Pecam;C85791;PECAM-1.
Summary  null
UniPort summary  Function  Induces susceptibility to atherosclerosis By similarity.Cell adhesion molecule which is required for leukocyte transendothelial migration(TEM)under most inflammatory conditions.Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment(LBRC)and is also essential for the LBRC membrane to be targeted around migrating leukocytes.Prevents phagocyte ingestion of closely apposed viable cells by transmitting ´detachment´ signals,and changes function on apoptosis,promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell´s active repulsion from the phagocyte.During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore.The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment).Isoform Delta15 is unable to protect against apoptosis.Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells(HUVEC).
Application Images :  
Western blot detection of PECAM1 antibody in THP-1 cell lysate using PECAM1 antibody (1:1000 diluted).Predicted band size: 130KDa.Observed band size: 130KDa.